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The Hippocratic corpus is a disparate group of texts relating primarily to medical matters composed between c.450 and c.250 bc and dealing with physiology, therapy, surgery, clinical practice, gynaecology and obstetrics, among other topics. The treatises are (for the most part) notable for their sober naturalism in physiological theory, their rejection of supernatural explanations for disease, and their insistence on the importance of careful observation. Although embodying a variety of different physiological schemes, they are the origin of the enormously influential paradigm of humoral pathology. In antiquity, the authorship of the entire corpus was mistakenly ascribed to the semi-legendary doctor Hippocrates of Cos (fl. c.450 bc).